What is the 2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid?

2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid is , while it's Molecular Formula is C12H19NO2. Mirogabalin is a two alpha2delta ligand which is investigated for the treatment of peripheral neuropathic pain, postherpetic neuralgia and fibromyalgia, showing promising results in patients with diabetic peripheral neuropathy.

What is the CAS number for 2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid?

The CAS number of 2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid is 1138245-13-2.

What is 2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid (1138245-13-2) used for?

Mirogabalin is a calcium channel blocker with analgesic effects. It binds to the α2δ-1 and α2δ-2 subunits of voltage-dependent Ca2+ channels. Mirogabalin has potent and sustained analgesic effects (ED50 = 2.5 mg/kg) in rats with diabetes induced by streptozotocin (STZ; ). Mirogabalin does not inhibit activities associated with CNS adverse effects of analgesics, such as rotarod performance (ID50 = 9.4 mg/kg) or locomotor activity (ID50 = 43.9 mg/kg), at its effective dose. Formulations containing mirogabalin are in clinical trials for diabetic peripheral neuropathic pain.

What is the 2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid?

2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid is , while it's Molecular Formula is C12H19NO2. Mirogabalin is a two alpha2delta ligand which is investigated for the treatment of peripheral neuropathic pain, postherpetic neuralgia and fibromyalgia, showing promising results in patients with diabetic peripheral neuropathy.

What is the CAS number for 2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid?

The CAS number of 2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid is 1138245-13-2.

What is 2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid (1138245-13-2) used for?

Mirogabalin is a calcium channel blocker with analgesic effects. It binds to the α2δ-1 and α2δ-2 subunits of voltage-dependent Ca2+ channels. Mirogabalin has potent and sustained analgesic effects (ED50 = 2.5 mg/kg) in rats with diabetes induced by streptozotocin (STZ; ). Mirogabalin does not inhibit activities associated with CNS adverse effects of analgesics, such as rotarod performance (ID50 = 9.4 mg/kg) or locomotor activity (ID50 = 43.9 mg/kg), at its effective dose. Formulations containing mirogabalin are in clinical trials for diabetic peripheral neuropathic pain.

Product classification

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Mirogabalin

Product Name: Mirogabalin
CasNo: 1138245-13-2
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Product Details

CasNo： 1138245-13-2

Molecular Formula： C12H19NO2

Manufacturer supply high quality Mirogabalin 1138245-13-2 with GMP standards

Molecular Formula:C12H19NO2
Molecular Weight:209.288
Boiling Point:357.5±15.0 °C(Predicted)
PKA:4.65±0.10(Predicted)
PSA：63.32000
Density:1.104±0.06 g/cm3(Predicted)
LogP:2.48270

1138245-13-2 Relevant articles

Novel method for preparing Mirogabalin

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, (2020/05/30)

The invention relates to a novel method ...

METHOD FOR PRODUCING OPTICALLY ACTIVE BICYCLIC -AMINO ACID DERIVATIVE

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Paragraph 0170; 0171, (2015/05/26)

An object of the present invention is to...

BICYCLIC -AMINO ACID DERIVATIVE

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Page/Page column 45, (2010/06/17)

It is intended to provide a bicyclic γ-a...

1138245-13-2 Process route

: (1R)-1-phenylethanaminium [(1R,5S,6S)-6-cyano-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetate

: 1138245-13-2
DS-5565

Conditions

Conditions	Yield
(1R)-1-phenylethanaminium [(1R,5S,6S)-6-cyano-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetate; With hydrogenchloride; In water; toluene; With hydrogen; In tert-butyl methyl ether; at 20 ℃; for 3h; under 3040.2 Torr; With potassium hydroxide; In tert-butyl methyl ether; water; for 0.5h;	88%

: C₁₂H₁₉NO₂*ClH

: 1138245-13-2
DS-5565

Conditions

Conditions	Yield
C₁₂H₁₉NO₂ClH; With* sulfuric acid; (S)-Mandelic acid; In methanol; isopropyl alcohol; at 40 ℃; for 0.5h; With sodium hydroxide; In tetrahydrofuran; water; at 20 - 40 ℃; for 2h;	76%

1138245-13-2 Upstream products

1138246-20-4
tert-butyl [(1R,5S,6S)-6-(tert-butoxycarbonylamino)methyl-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetate
1235479-61-4
(1R,5S)-3-ethylbicyclo[3.2.0]hept-3-en-6-one

1138245-13-2 Downstream products

1138245-21-2
[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid monobenzenesulfonate

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