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1.What is the Dihexa ?
Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer’s disease.
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1401708-83-5
N-hexanoic-L-tyrosine-L-isoleucine-(6)-aminohexanoic amide
Conditions
| Conditions |
Yield |
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Multi-step reaction with 2 steps
1.1: lithium hydroxide monohydrate / N,N-dimethyl-formamide / 20 °C
2.1: palladium 10% on activated carbon; hydrogen / acetic acid / 2 h
2.2: pH 8
With
lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen;
In
acetic acid; N,N-dimethyl-formamide;
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2.What is the CAS number for Dihexa ?
The CAS number of Dihexa is 1401708-83-5.
More information of Dihexa 1401708-83-5 are:
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CAS Number
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1401708-83-5 |
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Density
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1.111±0.06 g/cm3(Predicted) |
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Boiling Point
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866.2±65.0 °C(Predicted) |
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PSA
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150.62000 |
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LogP
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4.56560 |
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Pka
|
9.83±0.15(Predicted) |
3.What are another words for Dihexa ?
Synonyms for Dihexa 1401708-83-5:Dihexa
4.What is the molecular formula of Dihexa?
The chemical formula of Dihexa is C27H44N4O5 which containing 27 Carbon atoms,44 Hydrogen atoms,4 Nitrogen atoms and 5 Oxygen atoms,and the molecular weight of Dihexa is 504.67.
5.What is Dihexa (1401708-83-5) used for?
Dihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.
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6.Buy Dihexa with the best price .
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