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CasNo: 114-07-8
Molecular Formula: C37H67NO13
Appearance: white to off white crystalline powder
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Erythromycin is an antibiotic in the macrolide family that also has promotility effects because it is a motilin agonist.
Labeled Erythromycin, intended for use as an internal standard for the quantification of Erythromycin by GC- or LC-mass spectrometry.
erythromycin A N-oxide
erythromycin
Conditions | Yield |
---|---|
With
hydrogen;
Raney-Ni (W4);
In
ethanol;
at 25 ℃;
for 1h;
|
84% |
With
hydrogen;
Rany Ni (W4);
In
ethanol;
at 25 ℃;
for 1h;
|
84% |
erythromycin thiocyanate A
erythromycin
Conditions | Yield |
---|---|
With
sodium hydroxide;
In
methanol;
at 40 ℃;
pH=9-9.8;
|
99.33% |
With
ammonia;
In
dichloromethane; water;
at 25 - 35 ℃;
|
|
In
dichloromethane; water;
at 37 ℃;
pH=12;
Product distribution / selectivity;
|
|
With
ammonia;
In
water;
at 35 - 70 ℃;
for 1.5h;
Reagent/catalyst;
|
106 g |
The CAS number of Erythromycin is 114-07-8.
More information of Erythromycin 114-07-8 are:
CAS Number |
114-07-8 |
Density |
1.209 g/cm3 |
Melting Point |
138-140 °C |
Boiling Point |
818.401 °C at 760 mmHg |
Flash Point |
448.753 °C |
Vapor Pressure |
4.94E-31mmHg at 25°C |
Refractive Index |
-74 ° (C=2, EtOH) |
HS CODE |
3004.20 |
PSA |
193.91000 |
LogP |
1.78560 |
Pka |
8.8(at 25℃) |
Synonyms for Erythromycin 114-07-8:Erythromycin A;Erymax;Pentadecanoic acid, 3-[(2, 6-dideoxy-3-C-methyl-3-O-methyl-.alpha.-L-ribo-hexopyranosyl)oxy]- 6,11,12,13-tetrahydroxy-2,4,6,8,10,12-hexamethyl-9-oxo-5-[[3,4, 6-trideoxy-3-(dimethylamino)-.beta.-D-xylo-hexopyranosyl]oxy]-, .mu.-lactone, [2R-(2R*,3S*,4S*,5R*,6R*,8R*,10R*,11R*,12S*,13S*)]-;Taimoxin-F;EM;Abomacetin;Abboticin;Erythro;Kesso-Mycin;Erythromid;Erycin;Propiocine;Ilotycin;Prestwick_205;6-(4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione;Oxacyclotetradecane-2,10-dione, 4-[(2, 6-dideoxy-3-C-methyl-3-O-methyl-.alpha.-L-ribo-hexopyranosyl)oxy]- 14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4, 6-trideoxy-3-(dimethylamino)-.beta.-D-xylo-hexopyranosyl]oxy]-, [2R-(2R*,3S*,4S*,5R*,6R*,8R*,10R*,11R*,12S*,13S*)]-;
The chemical formula of Erythromycin is C37H67NO13 which containing 37 Carbon atoms,67 Hydrogen atoms,1 Nitrogen atoms and 13 Oxygen atoms,and the molecular weight of Erythromycin is 733.938.
Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It is active against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s = 0.015-2.0 mg/l). Erythromycin (10-40 mg/kg) dose-dependently inhibits the growth of S. aureus in a mouse model of thigh infection. It also inhibits the cytochrome P450 (CYP450) isoform CYP3A4 in vitro with IC50 values of 33 and 27.3 μM for α-hydroxytriazolam and 4-hydroxytriazolam formation, respectively, following administration of triazolam, which is known to be metabolized primarily by CYP3A4. Formulations containing erythromycin have been used in the treatment of bacterial respiratory and skin infections, pertussis, and a variety of other bacterial infections.
InChI:InChI=1/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21?,22-,23+,24+,25-,26+,28-,29?,30?,31+,32?,34?,35-,36-,37-/m1/s1
Relevant articles related to Erythromycin:
Article |
Source |
A NOVEL PROCESS OF LIBERATION OF ERYTHROMYCIN AND PREPARATION OF ITS SALTS |
- Page/Page column 12, (2014/09/29) |
CRYSTALLIZING METHOD OF ERYTHROMYCIN |
- Page/Page column 3, (2011/07/30) |
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