Chinese Manufacturer supply Ciprofloxacin HCl Bp 86393-33-1 in stock with high standard
- Molecular Formula:C13H9ClFNO3
- Molecular Weight:281.671
- Appearance/Colour:off-white crystalline powder
- Vapor Pressure:1.56E-09mmHg at 25°C
- Melting Point:242-245 °C(lit.)
- Boiling Point:467.3 °C at 760 mmHg
- PKA:6.36±0.41(Predicted)
- Flash Point:236.4 °C
- PSA：59.30000
- Density:1.652±0.06 g/cm3(Predicted)
- LogP:2.82710
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid(Cas 86393-33-1) Usage
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General Description
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7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, also known as fluoroquinolonic acid, can be prepared from ethyl 2,4-dichloro-5-fluorobenzoylacetate. It is formed as an intermediate during the synthesis of ciprofloxacin hydrochloride, a fluorinated quinolone antibacterial drug. |
InChI:InChI=1/C13H9ClFNO3/c14-9-4-11-7(3-10(9)15)12(17)8(13(18)19)5-16(11)6-1-2-6/h3-6H,1-2H2,(H,18,19)/p-1
86393-33-1 Relevant articles
An operational transformation of 3-carboxy-4-quinolones into 3-nitro-4-quinolones via ipso-nitration using polysaccharide supported copper nanoparticles: Synthesis of 3-tetrazolyl bioisosteres of 3-carboxy-4-quinolones as antibacterial agents
Azad, Chandra S.,Narula, Anudeep K.
, p. 19052 - 19059 (2016/03/01)
Chitosan supported Cu nano-particles hav...
ANTIVIRAL AND ANTIMICROBIAL COMPOUNDS
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Paragraph 0120; 0124; 0125, (2014/03/25)
Disclosed are guanidine and biguanidine ...
Synthesis, characterization and biological studies of some homodinuclear complexes of zinc with second-generation quinolone drug and neutral bidentate ligands
Patel,Chhasatia,Dosi,Bariya,Thakkar
scheme or table, p. 1918 - 1924 (2010/08/21)
The novel homodinuclear zinc(II) complex...
Synthesis of amide derivatives of quinolone and their antimicrobial studies
Patel,Patel,Chauhan
, p. 126 - 134 (2008/02/09)
A series of 1 -cyclopropyl-6-fluoro-1,4-...
86393-33-1 Process route
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86483-54-7
ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylate
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86393-33-1,178489-04-8
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
Conditions
| Conditions |
Yield |
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With
sulfuric acid;
In
water;
for 1.5h;
Heating;
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93%
|
|
With
sodium carbonate;
In
water;
for 0.166667h;
microwave irradiation;
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88%
|
|
With
hydrogenchloride;
In
ethanol;
at 120 - 130 ℃;
for 3h;
Yield given;
|
|
|
With
hydrogenchloride;
In
water;
|
|
|
With
sodium hydroxide; water;
at 20 ℃;
Heating / reflux;
|
|
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16173-58-3
N,N-dimethylaminoacrylic acid ethyl ester
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86393-34-2
2,4-dichloro-5-fluorobenzoyl chloride
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765-30-0
Cyclopropylamine
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86393-33-1,178489-04-8
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
Conditions
| Conditions |
Yield |
|
With
sodium hydroxide; potassium carbonate; acetic acid; triethylamine;
In
5,5-dimethyl-1,3-cyclohexadiene; water; isopropyl alcohol;
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86%
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86393-33-1 Upstream products
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86483-54-7
ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylate
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104599-90-8
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid methyl ester
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704-10-9
2,4-dichloro-5-fluoroacetophenone
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104600-21-7
methyl 3-cyclopropylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylate
86393-33-1 Downstream products
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85721-33-1
ciprofloxacin
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93106-60-6
enrofloxacin
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133210-96-5
1-cyclopropyl-7-chloro-6-piperazinyl-4-oxo-1,2-dihydroquinoline-3-carboxylic acid
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104599-90-8
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid methyl ester
English
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